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• Laboratory №7
• MIKHAIL V. BELOUSOV

MIKHAIL V. BELOUSOV

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  Senior research fellow, Candidate of Biological Sciences

  •   Laboratory of Proteomics of supra-organizational Systems №7
  •   Laboratory of Genomics of Supra-organizational Systems

  Information

  Graduated with honors from Voronezh State University, defended his thesis for the degree of Candidate of Biological Sciences in 2011. Since 2014, he has worked as a postdoc at St. Petersburg State University, doing research on yeast prions. Since 2018, he has been working at the FSBSI ARRIAM, where he is engaged in the search and study of new bacterial and plant amyloids. He is the author of more than 100 scientific publications, including two in the Nature Index. Head of three grants of the Russian Science Foundation, a grant from the President of the Russian Federation, five grants from the Government of St. Petersburg, performer of many other scientific grants.

  Publications and citations in databases: РИНЦ, WOS, Scopus, ORCID, PubMed, Google Scholar

  Selected publications: Fayoud H., Belousov, M.V., Antonets, K.S., Nizhnikov, A.A. Pathogenesis-associated bacterial amyloids: the network of interactions // Biochemistry (Moscow), 2024, V. 89(12), P. 2107-2132. DOI: 10.1134/S0006297924120022 Isakov N.A.; Belousov M.V.; Loglio G., Miller R., Nizhnikov A., Panda A., Noskov B.A. Cupin-1.1 Adsorption Layers at the Surface of 8M Urea Solutions // Journal of Physical Chemistry B, 2024, V. 128(48), P. 11992-11998. DOI: 10.1021/acs.jpcb.4c05607 Isakov N.A.; Belousov M.V.; Nizhnikov A.A.; Noskov B.A. Dynamic properties of the layers of cupin-1.1 aggregates at the air/water interface // Biophysical Chemistry, 2024 V. 307, 107166 DOI: 10.1016/j.bpc.2023.107166 Belousov M.V., Kosolapova A.O., Fayoud H., Sulatsky M.I., Sulatskaya A.I., Romanenko M.N., Bobylev A.G., Antonets K.S., Nizhnikov A.A. OmpC and OmpF outer membrane proteins of Escherichia coli and Salmonella enterica form bona fide amyloids // International Journal of Molecular Sciences, 2023, V. 24(21), 15522 doi: 10.3390/ijms242115522 Sulatsky M.I., Belousov M.V., Kosolapova A.O., Mikhailova E.V., Romanenko M.N., Antonets K.S., Kuznetsova I.M., Turoverov K.K., Nizhnikov A.A., Sulatskaya A.I. Amyloid fibrils of Pisum sativum L. vicilin inhibit pathological aggregation of mammalian proteins // International Journal of Molecular Sciences, 2023, V. 24(16), 12932 doi: 10.3390/ijms241612932 Shikov A.E., Belousova M.E., Belousov M.V., Nizhnikov A.A., Antonets K.S. Salmonella-based biorodenticides: past applications and current contradictions // International Journal of Molecular Sciences, 2022, V. 23(23), 14595 doi: 10.3390/ijms232314595 Kosolapova A.O., Belousov M.V., Sulatsky M.I., Tsyganova A.V., Sulatskaya A.I., Bobylev A.G., Shtark O.Y., Tsyganov V.E., Volkov K.V., Zhukov V.A., Tikhonovich I.A., Nizhnikov A.A. RopB protein of Rhizobium leguminosarum bv. viciae adopts amyloid state during symbiotic interactions with pea (Pisum sativum L.) // Frontiers in Plant Science, 2022, 13, 1014699 doi: 10.3389/fpls.2022.1014699 Sokolov P.A., Rolich V.I., Vezo O.S., Belousov M.V., Bondarev S.A., Zhouravleva G.A., Kasyanenko N.A. Amyloid fibril length distribution from dynamic light scattering data // European Biophysics Journal, 2022, V. 51(4-5), P. 325-333. doi: 10.1007/s00249-022-01600-5 Kharkov B.B, Podkorytov I.S., Bondarev S.A., Belousov M.V., Salikov V.A., Zhouravleva G.A., Skrynnikov N.R. Role of rotational motion in diffusion NMR experiments on supramolecular assemblies: application to Sup35NM fibrils // Angewandte Chemie - International Edition, 2021. V. 60(28), 15441-15451. DOI: 10.1002/anie.202102408  Sulatskaya A.I., Kosolapova A.O., Bobylev A.G., Belousov M.V., Antonets K.S., Sulatsky M.I., Kuznetsova I.M., Turoverov K.K., Stepanenko O.V., Nizhnikov A.A. β-Barrels and Amyloids: Structural Transitions, Biological Functions, and Pathogenesis // International Journal of Molecular Sciences, 2021, V. 22(21), 113616. DOI: 10.3390/ijms222111316 Antonets K.S., Belousov M.V., Sulatskaya A.I., Belousova M.E., Kosolapova A.O, Sulatsky M.I., Andreeva E.A., Zykin P.A., Malovichko Y.V., Shtark O.Y, Lykholay A.N, Volkov K.V., Kuznetsova I.M, Turoverov K.K., Kochetkova E.Y., Bobylev A.G., Usachev K.S., Demidov O.N., Tikhonovich I.A. and Nizhnikov A.A. Accumulation of storage proteins in plant seeds is mediated by amyloid formation // PLOS Biology, 2020. V. 18(7), e3000564. doi: 10.1371/journal.pbio.3000564 Kosolapova A.O., Antonets K.S., Belousov M.V., Nizhnikov A.A. Biological Functions of Prokaryotic Amyloids in Interspecies Interactions: Facts and Assumptions // International Journal of Molecular Sciences, 2020. V. 21(19), 7240. DOI: 10.3390/ijms21197240 Sulatskaya A.I., Bondarev S.A., Sulatsky M.I., Trubitsina N.P., Belousov M.V., Zhouravleva G.A., Llanos M., Kajava A.V., Kuznetsova I.M., Turoverov K.K. Point mutations affecting yeast prion propagation change the structure of its amyloid fibrils // Journal of Molecular Liquids, 2020, V. 314, 113618. doi: 10.1016/j.molliq.2020.113618 Drozdova P.B., Barbitoff Y.A., Belousov M.V., Skitchenko R.K., Rogoza T.M., Leclercq J., Kajava A.V., Matveenko A.G., Zhouravleva G.A., Bondarev S.A. Estimation of amyloid aggregate sizes with semi-denaturing detergent agarose gel electrophoresis and its limitations // Prion, 2020, V. 14(1), P. 118-128. doi: 10.1080/19336896.2020.1751574 Kosolapova A.O., Belousov M.V., Sulatskaya A.I., Belousova M.E., Sulatsky M.I., Antonets K.S., Volkov K.V., Lykholay A.N., Shtark O.Y., Vasileva E.N., Zhukov V.A., Ivanova A.N., Zykin P.A., Kuznetsova I.M., Turoverov K.K., Tikhonovich I.A. & Nizhnikov A.A. Two Novel Amyloid Proteins, RopA and RopB, from the Root Nodule Bacterium Rhizobium leguminosarum // Biomolecules, 2019, V. 9(11), 694. DOI: 10.3390/biom9110694 Danilov L.G., Matveenko A.G., Ryzhkova V.E., Belousov M.V., Poleshuk O.I., Likholetova D.V., Sokolov P.A., Kasyanenko N.A., Kajava A.V., Zhouravleva G.A. & Bondarev S.A. Design of a new [PSI+]-no-more mutation in SUP35 with strong inhibitory effect on the [PSI+] prion propagation // Frontiers in Molecular Neuroscience, 2019, V. 12, 274. DOI: 10.3389/fnmol.2019.00274 Belousov M.V., Bondarev S.A., Kosolapova A.O., Antonets K.S., Sulatskaya A.I., Sulatsky M.I., Zhouravleva G.A., Kuznetsova I.M., Turoverov K.K., Nizhnikov A.A. M60-like metalloprotease domain of the Escherichia coli YghJ protein forms amyloid fibrils // PLOS ONE, 2018, V. 13(1), e0191317. DOI: 10.1371/journal.pone.0191317 Sokolov P.A., Belousov M.V., Bondarev S.A., Zhouravleva G.A., Kasyanenko N.A. FibrilJ: ImageJ plugin for fibrils' diameter and persistence length determination // Computer Physics Communications, 2017, V. 214, P. 199-206. DOI: 10.1016/j.cpc.2017.01.011 Matveenko A.G., Drozdova P.B., Belousov M.V., Moskalenko S.E., Bondarev S.A., Barbitoff Yu.A., Nizhnikov A.A., Zhouravleva G.A. SFP1-mediated prion-dependent lethality is caused by increased Sup35 aggregation and alleviated by Sis1 // Genes to Cells, 2016, V. 21(10), P. 1290-1308. DOI 10.1111/gtc.12444 Sulatskaya A.I., Kuznetsova I.M., Belousov M.V., Bondarev S.A., Zhouravleva G.A., Turoverov K.K. Stoichiometry and affinity of Thioflavin T binding to Sup35p amyloid fibrils // PLOS ONE, 2016, 11(5), e0156314. DOI: 10.1371/journal.pone.0156314   Grants: Head of the Russian Science Foundation Grant (24-26-00124), 2024-2025. Head of the Russian Science Foundation Grant (22-26-00276), 2022-2023. Head of the Russian Science Foundation Grant (19-76-00026), 2019-2021. Head of the St. Petersburg Government Grant Committee on Science and Higher Education (2019, 2020, 2022, 2023, 2024). Head of the grant of the President of the Russian Federation for state support of young Russian scientists - Candidates of Sciences (МК-512.2017.4), 2017-2018. Head of the grant of the Federal target program "Cadres", 2010-2011. The main contractor of the RGNF grants, 2017-2021. The main contractor of the St. Petersburg State University postdoctoral grant, 2014-2017. Performer of 7 different RFBR grants, 2015-2019.